Research

The White Horse Medical Practice is actively involved in medical research. Hundreds of our patients have volunteered to take part in trials we are running. Areas of research have included asthma, diabetes, infection, heart disease and arthritis.

You can choose whether your data is used for research or planning purposes, and can find out more information about this on the NHS website: www.nhs.uk

Current Studies

If you are interested in being involved in more complicated research, we are currently running the following studies:

ATHENA - This academic study wants to identify patients in the early stages of having shingles, to see if the addition of a commonly used medicine (amitriptyline) can reduce post-shingles pain. Please ask your clinician about participating if you are in the first 5 days of a shingle illness. More information can be found on the Athena study website: www.athena-study.bristol.ac.uk

CCP NEXT GENERATION - This study aims to identify patients with early arthritis by offering a unique blood test to patients with new musculoskeletal pains, or with immediate family members who have Rheumatoid Arthritis. Please ask your GP about this study if you think you might be eligible. 

PRINCIPLE - A national COVID study to investigate potential treatments that reduce the severity / duration of COVID symptoms. More information can be found on the Principle Trial website: www.principletrial.org

OPTIMAN - Does use of FENO assessment help us tailor asthma medication better? If you have asthma and would be interested to participate please call Bev Langford, respiratory research nurse on 07769 280289

We also contribute de-identified data to CPRD (Clinical Practice Research Datalink) for public health research. Individual patients cannot be identified from this information, but you are able to opt out if you prefer.

If you are interested in putting your name forward to be considered for these or future trials please contact Dr Hannah Ferrington, who is the research lead for the practice, or Debbie Warwick, our research nurse.

Published Results

Studies that WHMP patients were a part of and have now published their results

ANTLER - A placebo controlled study to look at whether remaining on (or coming off) anti-depressants reduced relapses of depression

Press Release: Long-term antidepressant use is effective, but many people can come off them safely – new research (www.theconversation.com)

Publication: Maintenance or Discontinuation of Antidepressants in Primary Care (www.nejm.org)

GP Perspectives Study - This was a study of GP attitudes and understanding, to help improve clinician education about endometriosis. At WHMP all departments participate in research like this because we are passionate about our roles. 

Publication: Navigating possible endometriosis in primary care: a qualitative study of GP perspectives (www.bjgp.org)

HOPE-e - This was a pilot study looking at how we might be able to treat painful hand arthritis with HRT. WHMP patients were involved in the study, as were the doctors, helping the study team refine the trial protocol for a much larger study in the future. 

Publication: Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial (www.biomedcentral.com)

Psychological Impact of COVID - This was a study that many of our patients were involved in, by replying to a text link questionnaire. Over 28000 adults took part across the UK, with interesting insights into what affected mental health during the 2020 lockdown period. 

Publication: Impact of lockdown relaxation and implementation of the face-covering policy on mental health: A United Kingdom COVID-19 study (www.wjgnet.com)

STOIC - A world-leading study that proved inhaled steroids can reduce COVID illness severity and hospital admissions in some patients. WHMP and our patients were part of the hugely significant study that we are especially proud of. 

Publication: Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial - The Lancet Respiratory Medicine (www.thelancet.com)